Many people are surprised to see a big spider in the spring thinking that all spiders die in the winter then the eggs hatch. Actually spiders have a two year life cycle under normal conditions, so when that large spider comes out in the spring...he's hungry.
Will that large spider create a worse bite? Spiders survive by using their venom to immobilize and in some cases, break down the cell tissue of the victim. They need a reserve of that venom to survive. So much like a rattlesnake, a smaller spider or baby rattlesnake is more likely to inject too much venom whereas the adult has learned to control that flow to preserve it.
Yes a large spider will have a larger venom sack, but is less likely to use it in the first bite. When we see severe bites we usually see two or three other smaller bites with less infection where the spider was warning the person sitting on him, the third bite was in desperation and that is the bite that will have the most venom.
Treatment and how to identify what kind of spider bit you can be found at www.gtmpestcontrol.com, especially for the treasure valley area of Idaho.
Spiders do not see us as prey, only as a threat, so the bite is defensive.